Abstract: According to the characteristics of CO₂+O₂ in-situ leaching technology,a roller bottle leaching device with CO₂+O₂ pressure was designed for the rock core samples of sandstone uranium deposit in Xinjiang province.The lab leaching experiments were conducted with the roller bottle.The results indicated that the uranium leaching rate could be reached 70%,when the pressure was 2.0 MPa and the ratio of liquid-solid was 10∶1.Using the method of multistage leaching and afterwards adding oxidants enhanced leaching,the uranium leaching rate was higher than 90%.The test showed that the uranium ore deposit is suitable for CO₂+O₂in-situ leaching technology.The parameters obtained from the experiment will provide reference and guidance for mine engineering design and field conditions tests