Abstract: On the basis of the current mathematical model of mineral processing, the paper utilized Simulink's software tool in the MATLAB, constructed the grinding blockset and floatation blockset, and introduced the rule to construct the model. According the computer simulation, the batch grinding trial results showed that the simulation system explained reasonably the objective rule of batch grinding, and the recovery rate of batch floating trial results were closed to the same of the cited test data. It proved that the computer machine simulation being based on MATLAB/Simulink was applicable to the optimized control in the mineral processing plant.