Abstract: This paper analyzed continuous data in a period of 14 years for monitoring wastewater in tailings reservoir of an iron lead-zinc pyrtie mine,and investigated the infection of high acid and high alkali situation to heavy metals dissolve from sulfide in tailings.Relation curve of pH value to concentration of heavy metals pollution is revealed.Control techniques of acidification and heavy metals pollution of wastewater in tailings reservoir is put forward,including obturating and overlaying surface of tailings reservoir to isolate contact sulfide with water or oxygen to produce H⁺,appending alkali matter to neutralize H⁺ in order to cut off the reaction chain of heavy metal ion dissolving.