Abstract: In light of the characteristics of copper-lead-zinc close intergrowth and fine dissemination size of a multi-metallic sulphide ore,a flotation flowsheet consisting of Cu-Pb bulk flotation-regrinding and reflotation of Cu-Pb rougher concentrate-Znic flotation was adopted and tested.Based on the systemic condition tests,the separation of copper from lead and zinc was realized successfully.The copper concentrate with Cu grade of 21.05% and 86.71% recovery,lead concentrate with Pb grade of 63.94% and 851 53% recovery,and zinc concentrate with Zn grade of 571 40% and 85171% recovery are obtained respectively.It provides an experimental basis for the reasonable recover of these mineral resources.