Abstract: Maliping Pb-Zn deposit is located in the northeast in Yunnan Province, and in the in central of Zhaotong-Qujing lead-zinc metallogenic belt which belongs to Sichuan, Yunnan, and Guizhou lead-zinc metallogenic province. The ore body output from Yuhucun formation in the lower Cambrian dolomite and siliceous dolomite with phosphorus, carbon and argillaceous, interlayer fracture zone and feather fractures of siliceous rock, whose output form was layer, lenticular, ande vein. There were metallogenic characteristics of hydrothermal-emanation-sedimentation, was similar to the Irish-type of the Sedex-type class. Emeishan basalt magma and tectonic activities impact on the deposit and made it remoulded in late Permian. Content of ore-forming elements and the major elements of statistical analysis results indicate, in the ore-bearing hydrothermal alkali less conducive to the mineral and aluminum components.Ore-forming elements and content of the main elements of statistical analysis results indicate, less alkalis and aluminum components in the ore-bearing hydrothermal fluid is benefit for mineral dissolution and precipitation, too much iron may also cause compete occupy mineralizer sulfur. Metasomatism reaction between ore-bearing hydrothermal and carbonate rock could be the key role of mineral precipitation process. Statistical analysis of the ore-forming elements and trace elements show that Pb-Zn mineralization in this area mainly is relate with warm fluid mineralization by means of hot brine deposition.