Abstract: Aiming at the problems of low-grade lead-zinc mixing ore during mineral separation in Wulagen lead-zinc mine,six aspects technological optimization and remould were used,including the size of crushing and screening,ball added ratio,pharmacy system,stirring thick paste flotation heavily,coarse roughing and concentrating-zinc rough regrinding and reelection under grading and lead selection process.The problem of low lead recovery rate and low zinc recovery rate and zinc concentrate containing high silicon is solved,making the producing process is more stable and efficient.It achieves the excellent separating index of 52.19% lead concentrate grade,lead recovery of 83.17%,56.56%zinc concentrate grade,zinc recovery of 75.58% and 3.93% silica contained in zinc concentration,under 0.30% grade lead,2.81% zinc grade and 23.61% zinc oxide rate conditions in the ore.