Abstract: The chapter analyzes the geological condition,hydrogeological condition,engineering geological condition and technological mineralogical character of in-situ fragmentation leaching uranium,and discovers that differnet geological factor affect implement of in-situ fragmentation leaching uranium technology.But previously prospecting and geological condition evaluation of uranium ore is base on traditional mining method,we mine deposits by in-situ fragmentation leaching uranium method,must newly evaluate previously prospecting deposits before deposits are mined,or evaluate new prospecting deposits according to geological condition of in-situ fragmentation leaching uranium method.