Abstract: In Guizhou province, 4.251 billion tons of phosphorite resources have been identified, 80.7 thousand tons of iodine resources associated with phosphorite, 858.9 thousand tons of rare earth ores and 41.79 million tons of fluorine resources.Phosphate and its associated mineral resources are abundant.Phosphate ore has an annual output of about 17 million tons and an industrial output value of 5.3 billion yuan, accounting for about 10% of the province.The associated iodine and fluorine resources have been comprehensively utilized.On the basis of in-depth study of the present situation of the development and utilization of phosphate and its associated minerals, there are five problems found.The first problem is the lack of management of associated fluorine resources.The second problem is that the industrial production technology of associated rare earth ores has not been broken.The third problem is the conflict between mining and paleontological heritage conservation.The fourth problem is the contradiction between mining development and ecological protection.The fifth problem is the imperfect comprehensive utilization of relevant laws and regulations.The suggestions are put forward in five aspects.The first aspect is to establish the index of associated fluorine industry and to integrate fluorine resources into statistical management.The second aspect is to strengthen the combination of production, learn and research to promote the industrial production technology of associated rare earth elements.The third aspect is to firmly establish the concept of ecological civilization construction and strengthen the combination of mining development and cultural construction.The fourth aspect is that we should adhere to the two bottom lines of development and ecology, solve the ecological problems arising from mining development.The fifth aspect is to establish and improve the relevant laws and regulations of comprehensive utilization and promote the legalization of comprehensive utilization of mining industry.