Abstract: The safety of rock slopes affects the economic benefits of mines.In order to improve the stability of rock slope in open-pit mine, the response characteristics of rock slope near blasting area to blasting vibration are studied.Taking blasting excavation of an open-pit mine as engineering background, the location of measuring points on the slope is determined by theoretical analysis and on-site geological conditions, and the propagation law of blasting vibration wave on the slope is studied.The slope model is established by FLAC^3D software, and the change characteristics of velocity and displacement of rock slope under blasting vibration are analyzed and compared with the field monitoring results.The results show that the vertical vibration velocity of the measured points of the high slope is larger than that of the horizontal direction, and the magnification effect of blasting vibration appears when the height difference reaches a certain level; the vertical and horizontal deformation of the slope occurs in a small part, but the horizontal displacement of the bottom of the slope varies greatly and concentrates, which reduces the stability of the slope and reduces the model.The simulation results can provide guidance for accurate evaluation of rock slope safety and optimization of blasting parameters.