Abstract: The mining of low grade and gently inclined multilayer parallel gold veins has always been a difficult point in mining work.At present,there are few successful mining cases with safety,high efficiency and low lean loss.The grade of gently inclined ore body in Shishudi gold mine is very low,and many ore veins are seriously compounded.The mining technology is very difficult.Many years of open stope mining has left large-scale goaf group,which seriously threatens the safety of deep stope operation.Therefore,it is necessary to transform and upgrade to a safe and efficient filling mining method.Through the technical comparison of several schemes,the mechanized upward horizontal slicing and filling method is selected as the main mining scheme.The mechanized equipment such as rock drilling jumbo and scraper is configured to reduce the labor cost.The single-step interval mining and non-cemented filling process are adopted to reduce the filling cost to the greatest extent.The low grade and gently inclined multilayer parallel gold veins is safe and efficient low loss and low cost mining.The successful application of mechanized upward horizontal slicing and filling method in Shishudi gold mine provides a new idea for safe and efficient mining of low grade,gently inclined and multilayer parallel gold veins at home and abroad.