Abstract: Regional groundwater flow field is the basis of solute transport in groundwater and its distribution is the premise of judging the influence range of groundwater environment in in-situ leaching uranium mine.It is very important to accurately predict the change of regional flow field for guiding mine production practice.Taking an in-situ leaching uranium mine in northern China as the research object, this paper reproduces the variations of groundwater flow field in the whole mining area since its production by using numerical simulation method.The results show that the pumping and injection activities of production wells are the fundamental reason for the changes of the regional groundwater flow field.Due to the pumping and injection activities of production wells, a small range of water head rising area will be formed around the injection wells and the injection wells form point sources, while the water head drop area around the pumping wells will become point sinks.However, the total pumping volume during production is larger than the total injection volume, and the whole mining area has formed a clear head drop area.The regional cone depression can effectively control the migration range of dissolved components in the leaching solution.Combined with the background values and monitoring data of pH value, uranium and sulfate in groundwater in mining area, the control effect of regional groundwater flow field on the migration range of dissolved components in groundwater is further confirmed.It is concluded that the environmental impact of groundwater in the in-situ leaching uranium mine is controlled within 150 m.