Abstract: Natural uranium is an important strategic resource to ensure the development of nuclear power and national security in China.To meet the increasingly urgent domestic demand for uranium resources and solve the technical bottleneck restricting in-situ leaching of the low-permeability sandstone-type uranium deposits, a cave permeability enhancement technology is proposed, and its applicability in low-permeability sandstone-type uranium deposits is investigated.Relying on the Nalinggou Uranium Deposit, a mathematical model of cave permeability enhancement operation is constructed based on the theories of seepage and rock mechanics.A numerical simulation study is carried out using COMSOL software for the improvement of cave size and permeability formed by the cave permeability enhancement under different operation methods and times.Results show that the effect of continuous operation is better than that of the constant pressure field operation method.The permeability improvement zone mainly occurred in the control range of the high pressure distribution zone, the radius of the permeability improvement zone is approximately 20 m after 10 times of cave permeability enhancement operations, and the permeability improvement near the borehole can reach 10-20 times.The cave permeability enhancement technology has a better effect in the low-permeability sandstone uranium deposits, and is suitable for improving the permeability of the low-permeability sandstone uranium deposits in China.