Lop Nur salt lake is one of the largest Quaternary dry salt lakes in the world, with a rare amount of glauberite, and formed a large liquid salt lake potash deposit.The salt lake potash deposit in Luobei depression has been mined for more than ten years.It is of great significance to check the consumption of mineral resources and verify the reserves of resources to guide future production and mining design.For a long time, the block method is used for manual calculation of brine potash resource reserves, which is cumbersome and inefficient.The block method is simple to describe the spatial form of the brine storage structure, insufficiently described the heterogeneity of geological parameters, and human factors have a great influence, leading to inevitable deviations.This paper proposes to use the geostatistics delineation method based on GMS software to calculate.This method establishes a 3D ore body model and uses Kriging block estimates to calculate and summarize reserves.Compared with the geological block method, this method can be better in "rounding area" and "calculating reserves".Statistically speaking, it is a method for unbiased and optimal estimation of the value of regionalized variables in a limited area based on the correlation and variability of variables, which can greatly eliminate the trouble of the above problems.Comparing the calculation results of the two methods, it can be seen that the consumption of potential brine calculated by geological block method and delineation method is 1.11×10⁹ m³ and 1.21×10⁹ m³ respectively, the relative error is 8.26%.The consumption of confined brine is 0.29×10⁹ m³ and 0.98×10⁹ m³ respectively, the difference between them is large, and the relative error is 70.82%.It can be seen from the analysis of reasons that the delineation method based on geostatistics can calculate the volume more accurately and conveniently.The geological parameters are distributed to each node through the stratum grid division interpolation, which well describes the heterogeneity of the stratum.The calculation process is efficient and fast, and the verified resource amount is more accurate.This method can also be applied to the estimation of other liquid mineral resources and reserves, and has good applicability.