Blast-hole layout design is an important part of open pit blasting, and the accuracy of design directly affects the quality of subsequent blasting construction.In order to improve the convenience and accuracy of blast-hole layout design, the blasting design business of open pit blasting is deeply analyzed and systematically studied.The blasting design software system is developed on the DIMINE digital mining software platform using C++ language.The system fully considers the flexibility of the definition of the blast-hole network parameters, and can meet the hole layout requirements under various complex hole network parameters.At the same time, from the hole layout design level, the influence of the sub-drilling of the upper mined bench blast-hole on the bench design hole position is considered, which improves the matching degree between the hole layout design and the construction site.The field engineering application results show that the software can meet the requirements of hole layout design in various blocks of uranium ore, completely change the situation of “multiple steps, complex operation and low efficiency” of the current hole layout mode, greatly improve the work efficiency and hole layout design accuracy, and lay a good foundation for the subsequent fine blasting construction.