Abstract: For a low-grade and refractory talc type molybdenum ore in Henan Province, part of the argillized talc is removed through the pre desliming process, and then flotation is carried out. Under the condition that the molybdenum grade of the raw ore sample is 0.102% and the talc content is 15.21%, through two-stage pre desliming, one-stage rough separation, three-stage rough scavenging, five-stage fine separation and three-stage fine scavenging, the excellent indexes of molybdenum concentrate grade of 45.130% and molybdenum recovery rate of 74.96% can be obtained through the whole process closed-circuit test.