Abstract: Dynamic risk assessment and analysis of ground pressure disaster is one of the key technologies to restrict safe and efficient of deep mining. Towards a lead-zinc deposit in deep mining ground pressure disaster situation, the mining technological conditions were analysed. The deep ground pressure disaster risk microseismic monitoring system was designed and setted up. Blasting tests were carried out to calibrate coordinates, therefor, the speed model of key monitoring area system was optimized. The medium and long term spatial and temporal distribution of microseismic events in mine is analyzed, and the risk distribution characteristics of ground pressure disaster based on microseismic monitoring were indicated. The results show that, the comprehensive positioning error of the key monitoring area is less than 7.4m with the p-wave velocity of 5,400m /s and s-wave velocity of 3,200m /s, which can meet the requirements of the risk monitoring of deep mine ground pressure disaster. Microseismic events are mainly distributed in construction and mining area and isolated pillar area, and there is a positive correlation between microseismic activity and mining activity. Based on the analysis of time series distribution characteristics of microseismic events, it can be concluded that iI-1 # ore belt has a high risk of ground pressure activities, and Hongjianshan is prone to sudden and strong ground pressure events. The research results provide data support for the risk prevention and control of deep ground pressure disaster in the Lead-zinc Mine.