Abstract: Aiming at the problem of large lithium loss in desliming operation of a lithium mica ore, mineralogy of ROM is studied in detail, the main reason is sliming of fine scaly aggregates in grinding.A new type lepidolite collector BK414A is compounded which is based on the synergistic effect of anionic/cationic surfactants, and carried out flotation test for the lepidolite ore under the condition of no adjusting agents and desliming, and contrasted the indexes with conventional desliming-acid flotation process.The results show that in neutral pulp environment BK414A as a lepidolite collector obtained the concentrate with index of Li₂O grade 3.05% and Li₂O recovery 89.19%.In acid pulp environment(pH=4) the conventional desliming-acid flotation process obtained the concentrate with index of Li₂O grade 2.91% and Li₂O recovery 81.87%.Compared with the conventional acid flotation process, the new process obtained the concentrate with the Li₂O grade increased by 0.14%, and the Li₂O recovery increased by 7.32%.When using BK414A to float lepidolite, it is no need to add adjusting agents and desliming, and achieves full particle size flotation, and it also has the advantages of stable process, excellent flotation index, and realizes the efficient recovery of lepidolite in neutral pulp environment.