Abstract: Taking a copper-lead-zinc polymetallic ore in Inner Mongolia as the research object, technological mineralogy and experimental research on mineral processing tests of the ore are carried out. There are various kinds of minerals in the ore, and the mineral association is relatively complex. Lead is embedded in gangue as fine particles, which is easy to be lost in tailings, thus affecting the recovery rate of lead. The full selective flotation scheme is adopted, and the effects of grinding fineness, reagent dosage, pH value and other process factors on separation indexes are investigated. The results show that for the raw ore containing 0.67 % copper, 0.84 % lead and 4.24 % zinc, under the first-stage grinding fineness of 85% passing −0.074 mm, the copper flotation adopts the process of “two stage roughing-copper rough concentrate regrinding-three stage cleaning-two stage scavenging”, the lead flotation adopts the process of “one stage roughing-three stage cleaning-two stage scavenging”, and the zinc flotation adopts the process of “one stage roughing-three stage cleaning-three stage scavenging”, and the closed-circuit test obtains a copper concentrate containing 23.29% Cu with Cu recovery rate of 78.57%, a lead concentrate containing 54.58% Pb with Pb recovery rate of 57.18%, a zinc concentrate containing 47.39% Zn and Zn recovery rate of 80.70%. The research adopts a low-toxic, environment-friendly and exclusive reagent combination, which provides a reasonable process and process parameters for the development of ores, and realizes the comprehensive utilization of various valuable metal elements in ores.