Abstract: In order to reveal the deformation law of multi-media in different development stages in tight oil reservoir and study the effect of coupling of flow and deformation interaction on reservoir performances.The coupling of multiphase flow and reservoir deformation during fracturing and production was stated，based on the mechanics mechanism of multi-media deformation on tight sandstone reservoir，the dynamic model of reservoir parameters for different development stages and the multiphase seepage mathematical model were established.On this basis，an integration of fracturing and production software module was developed.The simulation results show that the pore expanded and the nature fracture opened once the injection pressure was higher than the opening pressure and the artificial fracture formed once the pressure was higher than the formation fracture pressure，as a result the reservoir porosity and permeability significantly increased in fracturing process.In the production process，since the decrease of pressure，the pore shrank and the fracture closed once the pressure was lower than the closing pressure，consequently the reservoir permeability decreased sharply.